Development of quinolone-resistant strains of Escherichia coli in stools of patients with cirrhosis undergoing norfloxacin prophylaxis: clinical consequences

Background/Aim: Norfloxacin prophylaxis decreases the incidence of bacterial infections in high-risk cirrhotic patients, but may promote the development of quinolone-resistant gram-negative bacteria in stools, and eventually lead to infections due to these bacteria. The aim of the study was to evalu...

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Bibliographic Details
Published in:Journal of hepatology 1999-08, Vol.31 (2), p.277-283
Main Authors: Aparicio, José Ramón, Such, José, Pascual, Sonia, Arroyo, Angeles, Plazas, Joaquín, Girona, Eva, Gutiérrez, Ana, Vera, Félix de, Palazón, José Maria, Carnicer, Fernando, Pérez-Mateo, Miguel
Format: Article
Language:English
Subjects:
Aged
Anti-Infective Agents - adverse effects
Anti-Infective Agents - therapeutic use
Antibiotic Prophylaxis - methods
Biological and medical sciences
Cirrhosis
Cross Infection - microbiology
Cross Infection - prevention & control
Drug Resistance, Microbial
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - isolation & purification
Escherichia coli Infections - etiology
Escherichia coli Infections - microbiology
Feces - microbiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver Cirrhosis - drug therapy
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Norfloxacin - adverse effects
Norfloxacin - therapeutic use
Norfloxacin prophylaxis
Nosocomial bacterial infections
Other diseases. Semiology
Prospective Studies
Quinolone resistance
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Summary:Background/Aim: Norfloxacin prophylaxis decreases the incidence of bacterial infections in high-risk cirrhotic patients, but may promote the development of quinolone-resistant gram-negative bacteria in stools, and eventually lead to infections due to these bacteria. The aim of the study was to evaluate the prevalence of quinolone-resistant strains of E.coli in stools on admission, and the characteristics of any nosocomial infections. Methods: Eighty-three consecutively hospitalized cirrhotic patients were included in this prospective study. The presence of quinolone-resistant strains of E.coli in stools on admission, and the characteristics of any nosocomial infections were recorded. Results: Fourteen out of 83 patients (16.8%) showed quinolone-resistant E. coli in stools (Group I), and 69 did not (Group II). Thirteen out of 14 from Group I (92.8%) and 17/69 (24.6) from Group II had received primary or secondary prophylaxis with norfloxacin ( p
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(99)80225-6