Effect of Immediate Fluid Resuscitation on the Rate, Volume, and Duration of Pulmonary Vascular Hemorrhage in a Sheep Model of Penetrating Thoracic Trauma

• Published in: Annals of emergency medicine 1997-03, Vol.29 (3), p.392-399
• Main Authors: Sakles, John C, Sena, Matthew J, Knight, Derek A, Davis, Jessica M
• Format: Article
• Language: English
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Disease Models, Animal; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care; Fluid Therapy - adverse effects; Hemorrhage - etiology; Hemorrhage - therapy; Intensive care medicine; Medical sciences; Pulmonary Veins - injuries; Sheep; Thoracic Injuries - complications; Wounds, Penetrating - complications
• ISSN: 0196-0644; 1097-6760
• DOI: 10.1016/S0196-0644(97)70352-4

Study objective: To determine the effects of early fluid resuscitation on the rate, volume, and duration of hemorrhage using a sheep model of uncontrolled pulmonary vascular hemorrhage. Methods: Sixteen adult sheep were anesthetized and fitted with catheters to measure systemic and pulmonary artery pressures. A branch of the pulmonary vein was then lacerated through an anterolateral thoracotomy, and a chest tube was inserted to monitor hemorrhage volume. Eight animals were assigned to the immediate fluid (IF) resuscitation group and were given 30 mL/kg of lactated Ringer's solution over a period of 10 minutes; this treatment was repeated once if normotension was not achieved. The other eight animals received no fluid (NF) and served as nonresuscitated controls. Results: The IF animals had a mean hemorrhage volume of 3,494±1,525 mL, compared with 1,594±689 mL in the NF group ( P