Stereoselective synthesis and β-blocking activity of substituted ( E)- and ( Z)-4(1H)-[1-(3-alkylamino-2-hydroxypropyl)oximino]-2,3-dihydro-1,8-naphthyridine. Potential antihypertensive agents. Part VI

The synthesis of R-(+)- and S-(-)-isomers of substituted ( E)- and ( Z)-4(1H)-[1-(3-alkylamino-2-hydroxypropyl)-oximino]-2, 3-dihydro-1, 8-naphthyridine, in enantiomeric pure form, is described. These compounds showed an interesting β-blocking activity. Generally, the ( S)-enantiomers possess a slig...

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Bibliographic Details
Published in:European journal of medicinal chemistry 1998, Vol.32 (12), p.955-963
Main Authors: Ferrarini, P.L., Mori, C, Badawneh, M, Manera, C, Saccomanni, G, Calderone, V, Scatizzi, R, Barili, P.L.
Format: Article
Language:English
Subjects:
chiral 1,8-naphthyridine derivatives
iminoethers
β-adrenergic blockers
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Summary:The synthesis of R-(+)- and S-(-)-isomers of substituted ( E)- and ( Z)-4(1H)-[1-(3-alkylamino-2-hydroxypropyl)-oximino]-2, 3-dihydro-1, 8-naphthyridine, in enantiomeric pure form, is described. These compounds showed an interesting β-blocking activity. Generally, the ( S)-enantiomers possess a slighthly higher affinity for β receptors than the ( R)-enantiomers.
ISSN:0223-5234
1768-3254
DOI:10.1016/S0223-5234(97)89639-0