Effects of palm olein tocopherol and tocotrienol on lipid peroxidation, lipid profiles and glycemic control in non-insulin diabetes mellitus patients

• Published in: Nutrition research (New York, N.Y.) N.Y.), 1996-11, Vol.16 (11), p.1901-1911
• Main Authors: Wan Nazaimoon, WM, Sakinah, O, Gapor, A, Khalid, BAK
• Format: Article
• Language: English
• Subjects: aceites de palmas; aldehidos; aldehyde; aldehydes; azucar en sangre; Biological and medical sciences; blood lipids; blood serum; blood sugar; cholesterol; colesterol; complement alimentaire; diabete; diabetes; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; extractos vegetales; extrait d' origine vegetale; femme; hemolipidos; hombres; homme; huile de palme; lipid peroxidation; lipide; lipide sanguin; lipidos; lipids; lipoproteinas; lipoproteine; lipoproteins; Malondialdehyde (MDA); Management. Various non-drug treatments. Langerhans islet grafts; Medical sciences; men; mujeres; non-insulin dependent diabetes mellitus (NIDDM); olein; oleina; oleine; palm oils; palm olein; Palmvitee; peroxidacion lipidica; peroxides; peroxidos; peroxydation des lipides; peroxyde; plant extracts; serum sanguin; sucre du sang; suero sanguineo; suplementos; supplements; tocoferoles; tocopherol; tocopherols; tocotrienol; tocotrienoles; tocotrienols; trigliceridos; triglyceride; triglycerides; women
• ISSN: 0271-5317; 1879-0739
• DOI: 10.1016/S0271-5317(96)00213-8

Refined palm oil, palm olein contains very low amount of vitamin-E (0.01%, w w ) as compared to its tocotrienol-rich extract, Palmvitee, which contains about 20 % ( w w ) of vitamin E. The effects of palm olein intake on serum lipid peroxides or malondialdehyde (MDA) levels, lipid profiles and glycemic control of 32 non-insulin dependent diabetes mellitus patients were compared to those of Palmvitee using a double-blind study. Patients took six 300 mg capsules of Palmvitee or palm olein daily for 60 days, underwent a washout period of 60 days, crossed-over in treatments and continued for another 60 days. Subjects who consumed Palmvitee showed significant increase in tocopherol and tocotrienol (p=0.004 and p=0.02 respectively), while subjects who consumed palm olein showed increase only in tocopherol levels (p=0.04). MDA levels on day 60 in patients given palm olein were inversely correlated with tocopherol levels (r=-0.644, p=0.007). MDA (mean ± SEM) declined significantly (p < 0.001) following palm olein or Palmvitee intake, 1.33 ± 0.1 versus 1.07 ± 0.07 and 1.47 ± 0.09 versus 1.13 ± 0.06 nmol/l respectively. The decline continued to be significant (p < 0.001) during the washout period, then showed no further change thereafter. Neither palm olein nor Palmvitee hcaused significant changes in total cholesterol, HDL-chol, triglyceride, LDL-chol and glycemic control of the patients. This study showed that the small amount of vitamin E present in palm olein, was sufficient to significantly reduce lipid peroxidation and that increased intake of the vitamin, as in Palmvitee, did not cause further reduction in the peroxide levels.