Increasing magnesium intake prevents high phosphorus diet-induced kidney damage in young rats

• Published in: Nutrition research (New York, N.Y.) N.Y.), 1997-02, Vol.17 (2), p.325-337
• Main Authors: Matsuzaki, Hiroshi, Arai, Kazuyoshi, Uehara, Mariko, Suzuki, Kazuharu, Sato, Shigeru, Kanke, Yusuke, Goto, Shiro
• Format: Article
• Language: English
• Subjects: ACTIVIDAD ENZIMATICA; ACTIVITE ENZYMATIQUE; ALBUMINAS; ALBUMINE; ALBUMINS; ANIMAL MODELS; ANIMALES JOVENES; AZOTE; Biological and medical sciences; BLOOD SERUM; CALCIO; CALCIUM; CONTENIDO DE HUMEDAD; CONTENIDO MINERAL; CONTROL DE ENFERMEDADES; CONTROLE DE MALADIES; CREATININA; CREATININE; DAMAGE; DANOS; DEGAT; DIET; DIETA; DISEASE CONTROL; DISEASE PREVENTION; DOSAGE EFFECTS; ENFERMEDADES RENALES; ENZYMIC ACTIVITY; EXCRECION; EXCRETION; EXPERIMENTACION; EXPERIMENTATION; FISIOLOGIA DE LA NUTRICION; FONCTION PHYSIOLOGIQUE; FOSFORO; FUNCION FISIOLOGICA; GLOBULINAS; GLOBULINE; GLOBULINS; Histological examination; HISTOPATHOLOGIE; HISTOPATHOLOGY; HISTOPATOLOGIA; Increased magnesium intake; Indicator of kidney function; INGESTION DE NUTRIENTES; INGESTION DE SUBSTANCES NUTRITIVES; INTERACCIONES NUTRIENTE NUTRIENTE; INTERACTION NUTRIMENT NUTRIMENT; JEUNE ANIMAL; Kidney damage; KIDNEY DISEASES; KIDNEYS; MAGNESIO; MAGNESIUM; Medical sciences; MICROGLOBULINS; MINERAL CONTENT; MODELE ANIMAL; MODELOS ANIMALES; MOISTURE CONTENT; N-ACETYL-BETA-GLUCOSAMINIDASE; NEPHROCALCINOSIS; Nephrology. Urinary tract diseases; NEPHROPATHIE; NITROGEN; NITROGENO; NUTRIENT BALANCE; NUTRIENT INTAKE; NUTRIENT NUTRIENT INTERACTIONS; NUTRITION PHYSIOLOGY; ORINA; PESO; PHOSPHORE; PHOSPHORUS; PHYSIOLOGICAL FUNCTIONS; PHYSIOLOGIE DE LA NUTRITION; POIDS; RAT; RATA; RATS; REGIME ALIMENTAIRE; REIN; RINONES; SERUM SANGUIN; SUERO SANGUINEO; TENEUR EN EAU; TENEUR EN ELEMENTS MINERAUX; UREA; UREE; Urinary lithiasis; URINE; WATER CONTENT; WEIGHT; YOUNG ANIMALS
• ISSN: 0271-5317; 1879-0739
• DOI: 10.1016/S0271-5317(96)00262-X

Dietary magnesium preventive effect on high phosphorus diet-induced kidney damage was studied in young male rats. Rats were fed a purified diet containing 0.05%, 0.15% or 0.30% magnesium and 1.5% phosphorus for 21 days. On histological examination, dilatation of the distal tubules and collecting ducts and kidney calcification were observed in all groups. However, the degree of damage was reduced by increased magnesium intake. Tubular necrosis, inflammatory cell infiltration and interstitial edema in the cortex were observed in rats fed a 0.05% or 0.15% magnesium diet, but not shown in those fed a 0.30% magnesium diet. As an indicator of kidney function, serum urea nitrogen concentration was deceased in rats fed a 0.15% magnesium diet or 0.30% magnesium diet. Creatinine and urea clearance were increased with increase in magnesium intake. Urinary albumin excretion and activity of N-acetyl-β-D-glucosam inidase (NAG) in urine were decreased in rats fed a 0.30% magnesium diet. Urinary β 2-microglobulin excretion were decreased in rats fed a 0.15% magnesium diet or 0.30% magnesium diet. In conclusion, increased magnesium intake prevented high phosphorus diet-induced kidney damage.