Influence of food deprivation on sympathetic support of blood pressure in the spontaneously hypertensive rat

• Published in: Nutrition research (New York, N.Y.) N.Y.), 1998-09, Vol.18 (9), p.1581-1594
• Main Authors: Jones, Melaney A., VanNess, J.Mark, Casto, R.Michael, Overton, J.Michael
• Format: Article
• Language: English
• Subjects: animal models; Biological and medical sciences; blood glucose; blood pressure; body weight; Caloric Restriction; Energy Balance; Fasting; Feeding. Feeding behavior; females; fluid intake; food intake; Fundamental and applied biological sciences. Psychology; Gender; gender differences; heart rate; hematocrit; Hypertension; males; mean arterial pressure; nutrients; parasympatholytics; rats; sodium; starvation; Sympathetic Nervous System; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0271-5317; 1879-0739
• DOI: 10.1016/S0271-5317(98)00132-8

We examined the effects of short-term food deprivation on directly measured blood pressure and sympathetic support of blood pressure in male (n=7, 231±7 g) and female (n=9, 193±4 g) spontaneously hypertensive rats (SHR, Charles River). Carotid arterial catheters were inserted under halothane anesthesia for direct assessment of cardiovascular function in conscious, unrestrained rats. After several days of recovery, mean arterial blood pressure (MAP) and heart rate (HR) were determined prior to, during, and after food deprivation. Baseline MAP and HR were 170±14 mmHg and 351±13 beats/min in males and 187±6 mmHg and 354±9 beats/min in females. An overnight fast produced significant (P