Caroverine inhibits the conditioned place aversion induced by naloxone-precipitated morphine withdrawal in rats

Comparable to the anti-craving compound acamprosate, caroverine reduces alcohol withdrawal symptoms by an antagonism at ionotropic glutamate receptors and a blockade of calcium channels. The present study examines the effect of caroverine in a craving model, in which acamprosate has proved effective...

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Bibliographic Details
Published in:Neuroscience letters 2003-10, Vol.349 (2), p.91-94
Main Authors: Kratzer, U., Schmidt, W.J.
Format: Article
Language:English
Subjects:
Analgesics, Opioid - adverse effects
Animals
Avoidance Learning - drug effects
Biological and medical sciences
Caroverine
Conditioned place aversion
Conditioned withdrawal
Conditioning, Classical - drug effects
Craving
Male
Medical sciences
Miscellaneous
Morphine - adverse effects
Morphine pellet
Naloxone - pharmacology
Naloxone-precipitated withdrawal
Narcotic Antagonists - pharmacology
Place conditioning
Quinoxalines - pharmacology
Rats
Rats, Sprague-Dawley
Substance Withdrawal Syndrome - drug therapy
Substance Withdrawal Syndrome - physiopathology
Toxicology
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Summary:Comparable to the anti-craving compound acamprosate, caroverine reduces alcohol withdrawal symptoms by an antagonism at ionotropic glutamate receptors and a blockade of calcium channels. The present study examines the effect of caroverine in a craving model, in which acamprosate has proved effective before. A place aversion was induced by a conditioned morphine withdrawal by administration of the opioid antagonist naloxone (0.1 mg/kg, s.c.) 5–6 days after the subcutaneous implantation of a morphine pellet in rats. Testing in the drug-free state, the acquisition of a conditioned aversion against the naloxone-associated cues was inhibited by pretreatment with caroverine (5 mg/kg, i.p.). This result corroborates the involvement of excitatory glutamate and calcium in the development of conditioned withdrawal and craving. It offers further evidence for the hypothesis that these neuronal systems are altered during withdrawal in a similar way by ethanol and opiates.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(03)00783-3