Apomorphine-induced suppression of prey oriented turning in toads is correlated with activity changes in pretectum and tectum: [ 14C]2DG studies and single cell recordings

In common toads, after systemic administration of the dopamine agonist apomorphine (APO), prey-oriented turning was suppressed. Searching for neural correlates, the present study shows APO-induced increases in glucose utilization in the retinorecipient pretectum and dorsal optic tectum and a decreas...

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Bibliographic Details
Published in:Neuroscience letters 1996-12, Vol.220 (3), p.215-218
Main Authors: Glagow, M., Ewert, J.-P.
Format: Article
Language:English
Subjects:
Animals
Antimetabolites
Apomorphine
Apomorphine - pharmacology
Behavioral psychophysiology
Biological and medical sciences
Bufo bufo
Common toad
Deoxyglucose
Dopamine Agonists - pharmacology
Fundamental and applied biological sciences. Psychology
Glucose - metabolism
Glucose utilization
Neurons - drug effects
Neurons - physiology
Neurotransmission and behavior
Optic tectum
Predatory Behavior - drug effects
Pretectum
Prey-orienting
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Superior Colliculi - cytology
Superior Colliculi - drug effects
Superior Colliculi - physiology
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Summary:In common toads, after systemic administration of the dopamine agonist apomorphine (APO), prey-oriented turning was suppressed. Searching for neural correlates, the present study shows APO-induced increases in glucose utilization in the retinorecipient pretectum and dorsal optic tectum and a decrease in the medial tectal output layers. This pattern of metabolic activity is resembled by neuronal discharge activities recorded in response to a prey stimulus; the discharge rates are increased in retinal ganglion cells and pretectal neurons and decreased in tectal output neurons. We suggest that an APO-induced enhancement of pretecto-tectal inhibitory influences contributes to the reduction of tectal output, thus suppressing prey-oriented turning behavior.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(96)13272-9