Investigation of the triamterene– β-cyclodextrin system prepared by co-grinding

Complex formation of triamterene and β-cyclodextrin in solution was studied by phase solubility and spectral shift methods. The value of the apparent stability constant, K c, calculated by these techniques, were 340 and 470 M −1, respectively. Binary systems of triamterene and β-CD were prepared usi...

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Bibliographic Details
Published in:International journal of pharmaceutics 1997-07, Vol.153 (2), p.181-189
Main Authors: Arias, M.J, Moyano, J.R, Ginés, J.M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Dissolution rate
FTIR
Grinding
Medical sciences
Pharmacology. Drug treatments
SEM
Triamterene
Urinary system
β-cyclodextrin
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Summary:Complex formation of triamterene and β-cyclodextrin in solution was studied by phase solubility and spectral shift methods. The value of the apparent stability constant, K c, calculated by these techniques, were 340 and 470 M −1, respectively. Binary systems of triamterene and β-CD were prepared using the dry co-grinding method. Their characterization was performed by Fourier transform infrared spectroscopy and scanning electron microscopy. The main conclusion arising from these studies has been a high interaction between drug and carrier, linked to a clear increase in the amorphous nature of the drug in these systems. Finally, as expected, the 1 min co-ground system presented a notable improvement in its dissolution rate: up to five fold dissolution efficiency over the first 60 min over free drug. This might be attributed to the amorphous state, the increased wettability of the drug and the inclusion complex formation at the liquid state.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(97)00101-4