Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex

In vivo microdialysis offers a unique approach to monitor biochemical events related to brain function and metabolism, and has been used extensively in many systems to measure the release of endogenous transmitters and other neuroactive substances during normal and pathological conditions. The chara...

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Bibliographic Details
Published in:Hearing research 2003, Vol.175 (1), p.45-53
Main Authors: Liu, Junxiu, Li, Xuepei, Wang, Lei, Dong, Yu, Han, Huiwan, Liu, Guoquan
Format: Article
Language:English
Subjects:
5-HT
Animals
Auditory cortex
Auditory Cortex - drug effects
Auditory Cortex - metabolism
Biological and medical sciences
Dialysis Solutions - chemistry
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Glucose - analysis
Inferior Colliculi - drug effects
Inferior Colliculi - metabolism
Inferior colliculus
Lactic Acid - analysis
Medical sciences
Microdialysis
Non tumoral diseases
Otorhinolaryngology. Stomatology
Rats
Rats, Wistar
Salicylate
Salicylates - metabolism
Salicylates - pharmacology
Serotonin - analysis
Serotonin - metabolism
Tinnitus
Tinnitus - chemically induced
Tinnitus - metabolism
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Summary:In vivo microdialysis offers a unique approach to monitor biochemical events related to brain function and metabolism, and has been used extensively in many systems to measure the release of endogenous transmitters and other neuroactive substances during normal and pathological conditions. The characterization of neurotransmitters’ changes induced by salicylate in the inferior colliculus (IC) and the auditory cortex (AC) may provide insight into the action of salicylate on the auditory system and, through this, provide a better understanding of neurological mechanism of salicylate-induced tinnitus. In the present study, the effect of salicylate on 5-HT system in IC and AC has been monitored by microdialysis in salicylate-induced tinnitus animal models. Glucose and lactate levels in IC and AC were significantly increased after application of salicylate (350 mg/kg, i.p.), indicating a salicylate-related increase in regional neuronal activity. The 5-HT level increased to a maximum of 268±27% basal level in IC 2 h after application and of 277±24% basal level in AC around 3 h after application. These data suggest that the increases of 5-HT levels in IC and AC may be involved in the tinnitus generation.
ISSN:0378-5955
1878-5891
DOI:10.1016/S0378-5955(02)00708-6