Hypoglycaemic activity of Syzigium cumini seeds: effect on lipid peroxidation in alloxan diabetic rats

Syzigium cumini, commonly known as ‘jamun’, is widely used in Indian folk medicine for the treatment of diabetes mellitus. Oral administration of 2.5 and 5.0 g/kg body weight of the aqueous extract of the seed for 6 weeks resulted in a significant reduction in blood glucose and an increase in total...

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Bibliographic Details
Published in:Journal of ethnopharmacology 1998-05, Vol.61 (1), p.1-7
Main Authors: Prince, P.Stanely Mainzen, Menon, Venugopal P, Pari, L
Format: Article
Language:English
Subjects:
Alloxan
Animals
Antioxidants - therapeutic use
Biological and medical sciences
Blood Glucose - analysis
Catalase - analysis
Diabetes
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - drug therapy
experimental diabetes
Extract
General pharmacology
Glucose
Glutathione - analysis
Hemoglobins - analysis
Hypoglycaemic
hypoglycemic agents
Hypoglycemic Agents - therapeutic use
India
jamun
Lipid Peroxides - metabolism
Male
Medical sciences
Medicine, Traditional
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - administration & dosage
Plant Extracts - therapeutic use
Plants, Medicinal
Rats
Rats, Wistar
Seeds
Superoxide Dismutase - analysis
Syzigium cumini
Syzygium cumini
Thiobarbituric Acid Reactive Substances - analysis
traditional medicine
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Summary:Syzigium cumini, commonly known as ‘jamun’, is widely used in Indian folk medicine for the treatment of diabetes mellitus. Oral administration of 2.5 and 5.0 g/kg body weight of the aqueous extract of the seed for 6 weeks resulted in a significant reduction in blood glucose and an increase in total haemoglobin, but in the case of 7.5 g/kg body weight the effect was not significant. It also prevents decrease in body weight. The aqueous extract also resulted in decreased free radical formation in tissues studied. Thus the study shows that Jamun seed extract (JSEt) has hypoglycaemic action. The decrease in thiobarbituric acid reactive substances (TBARS) and increase in reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) clearly show the antioxidant property of the JSEt. The effect of JSEt was most prominently seen in the case of animals given 5.0 g/kg body weight. JSEt was more effective than glibenclamide.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(98)00002-6