Modelling of conditions for the enantiomeric separation of β2-adrenergic sympathicomimetics by capillary electrophoresis using cyclodextrins as chiral selectors in a polyethylene glycol gel

A two-factor central composite design was used to determine a mathematical model for prediction of the optimal conditions for the separation of the enantiomers of some widely used β 2-sympathicomimetic drugs ( β 2-agonists) by capillary electrophoresis using cyclodextrins (CD) as a chiral selector i...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1999-03, Vol.19 (3), p.529-537
Main Authors: de Boer, Theo de, Bijma, Rixt, Ensing, Kees
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Capillary electrophoresis
Cyclodextrins
Enantiomeric separation
General pharmacology
Mathematical model
Medical sciences
Optimisation
Pharmacology. Drug treatments
Polyethylene glycol
β2-Sympathicomimetics
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Summary:A two-factor central composite design was used to determine a mathematical model for prediction of the optimal conditions for the separation of the enantiomers of some widely used β 2-sympathicomimetic drugs ( β 2-agonists) by capillary electrophoresis using cyclodextrins (CD) as a chiral selector in a polyethylene glycolgel. The effects of the chemical structure of these drugs along with the addition of polyethylene glycol to the cyclodextrin solution on the resolution of their enantiomers were studied. To allow impurity studies down to 0.1% (distomer–eutomer) a resolution of 2.5 should be warranted. Those β 2-agonists containing two hydroxylic groups in the aromatic ring structure show the highest enantiomeric separation, due to the fact that one of their enantiomers has a better geometric structure to fit into the β-cyclodextrin cavity.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(98)00249-0