Effects of esmolol on patients with left ventricular dysfunction

• Published in: Journal of the American College of Cardiology 1986-07, Vol.8 (1), p.225-231
• Main Authors: Iskandrian, Abdulmassih S., Bemis, Charles E., Hakki, A.-Hamid, Panidis, Ioannis, Heo, Jaekyeong, Gerald Toole, J., Hua, Tsushung A., Allin, Douglas, Kane-Marsch, Sally
• Format: Article
• Language: English
• Subjects: Adrenergic beta-Antagonists - adverse effects; Adrenergic beta-Antagonists - therapeutic use; Aged; Antianginal agents. Coronary vasodilator agents; Biological and medical sciences; Blood Pressure - drug effects; Cardiac Output - drug effects; Cardiovascular system; Coronary Disease - drug therapy; Coronary Disease - physiopathology; Female; Heart Rate - drug effects; Heart Ventricles - diagnostic imaging; Heart Ventricles - physiopathology; Hemodynamics - drug effects; Humans; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Propanolamines - adverse effects; Propanolamines - therapeutic use; Radionuclide Imaging; Vascular Resistance - drug effects
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/S0735-1097(86)80117-6

This study examined the effect of esmolol, an ultrashort-acting beta-receptor blocker, in 10 patients with severe left ventricular dysfunction. Simultaneous hemodynamic and radionuclide angiographic measurements were obtained at incremental doses of esmolol (2,4, 8,12 and 16 mg/min). At a dose of 4 mg/min, esmolol produced bets blockade: a decrease in heart rate from 91 ± 4 to 83 ± 4 beats/min (p < 0.05) (mean ± SEM) and a decrease in systolic aortic pressure from 133 ± 5 to 128 ± 5 mm Hg (p < 0.05). At the maximal dose, the heart rate decreased to 79 ± 3 beats/min (p < 0.05) and biventricular function was depressed; the left ventricular ejection fraction decreased from 27 ± 2 to 21 ± 2% (p < 0.05) and the right ventricular ejection fraction decreased from 38 ± 2 to 29 ± 2% (p < 0.05). These changes were accompanied by increases in left ventricular end-diastolic volume (p < 0.05), left ventricular end-systolic volume (p < 0.05) and pulmonary artery wedge pressure (p < 0.05), as well as a decrease in cardiac output (p < 0.05). The hemodynamic abnormalities (which showed considerable interindividual variability) returned to near baseline levels 10 to 30 minutes after infusion was stopped. Thus, esmolol can be administered to patients with severe left ventricular dysfunction. The beneficial effect (beta-adrenergic blockade) is usually achieved with small doses without clinically important hemodynamic changes. At larger doses, however, significant changes in biventricular function may be observed.