Review of experimental male-mediated behavioral and neurochemical disorders

Paternal exposures to exogenous agents have been reported to produce a variety of developmental defects in the offspring. In experimental animals, these effects include decreased litter size and weight, increased stillbirth and neonatal death, birth defects, tumors, and functional/behavioral abnorma...

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Bibliographic Details
Published in:Neurotoxicology and Teratology 1996-11, Vol.18 (6), p.611-616
Main Authors: Nelson, B.K., Moorman, W.J., Schrader, S.M.
Format: Article
Language:English
Subjects:
Age Factors
Alcoholism
Animals
Biological and medical sciences
Cyclophosphamide - toxicity
Embryology: invertebrates and vertebrates. Teratology
Ethylene Dibromide - toxicity
Experimental animals
Female
Fundamental and applied biological sciences. Psychology
Humans
Lead Poisoning
Male
Male-mediated effects
Mental Disorders - chemically induced
Mental Disorders - genetics
Mental Disorders - physiopathology
Narcotics - toxicity
Nervous System Diseases - chemically induced
Nervous System Diseases - genetics
Nervous System Diseases - physiopathology
Neurobehavioral disorders
Neurochemical effects
Offspring
Paternal Exposure
Paternal exposures
Rats
Sex Characteristics
Teratology. Teratogens
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Summary:Paternal exposures to exogenous agents have been reported to produce a variety of developmental defects in the offspring. In experimental animals, these effects include decreased litter size and weight, increased stillbirth and neonatal death, birth defects, tumors, and functional/behavioral abnormalities—some of these effects being transmitted to the second and third generations. This article reviews the exogenous agents that have reportedly caused behavioral or neurochemical alterations in offspring of experimental animals following paternal exposures, including advanced age, alcohols, cyclophosphamide, ethylene dibromide, lead, opiates, and a few miscellaneous chemicals. Based upon the consistency of effects in several of these agents in a variety of studies in experimental animals, the conclusion is that paternal exposures may contribute to the incidence of neurobehavioral disorders in humans.
ISSN:0892-0362
1872-9738
DOI:10.1016/S0892-0362(96)00123-7