Zinc and liver cirrhosis: Biochemical and histopathologic assessment

Experimental liver cirrhosis was produced by administration of thioacetamide. Cirrhotic animals were divided into two groups: one group was given zinc sulphate and the second kept as cirrhotic control. Zinc-treated animals showed a restoration of normal hepatic and plasma zinc and copper levels. Sim...

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Bibliographic Details
Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 1997-03, Vol.13 (3), p.vi,206-vii,212
Main Authors: Dashti, Hussein M., Mathew, Thazhumpal C., Jadaon, Meherez M., Ashkanani, Eman
Format: Article
Language:English
Subjects:
Alanine Transaminase - analysis
Alanine Transaminase - blood
Alanine Transaminase - drug effects
Animals
Aspartate Aminotransferases - analysis
Aspartate Aminotransferases - blood
Aspartate Aminotransferases - drug effects
Bilirubin - analysis
Biological and medical sciences
Cohort Studies
Collagen - analysis
Copper - analysis
Copper - blood
Fibrin - analysis
gamma-Glutamyltransferase - analysis
gamma-Glutamyltransferase - blood
gamma-Glutamyltransferase - drug effects
Gastroenterology. Liver. Pancreas. Abdomen
Glycogen - analysis
histopathology
Liver - chemistry
Liver - drug effects
Liver - enzymology
Liver - pathology
liver cirrhosis
Liver Cirrhosis, Experimental - blood
Liver Cirrhosis, Experimental - chemically induced
Liver Cirrhosis, Experimental - pathology
liver function test
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Other diseases. Semiology
Rats
Rats, Wistar
Reticulin - analysis
thioacetamide
trace elements
Transferases - analysis
Transferases - blood
Transferases - drug effects
Zinc - analysis
Zinc Sulfate - administration & dosage
Zinc Sulfate - pharmacology
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Summary:Experimental liver cirrhosis was produced by administration of thioacetamide. Cirrhotic animals were divided into two groups: one group was given zinc sulphate and the second kept as cirrhotic control. Zinc-treated animals showed a restoration of normal hepatic and plasma zinc and copper levels. Similarly, plasma levels of aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl aminotransferase, and total bilirubin decreased significantly. Light microscopic studies showed that most of the hepatocytes appeared normal in zinc-treated as compared with untreated cirrhotic animals. The amount of fibrin, reticulin, and collage, which was high in the cirrhotic livers, decreased following zinc treatment. Staining with periodic acid Schiff's reagent showed the ability of heptatocytes to store glycogen after zinc treatment. These results revealed that zinc may have some beneficial effect in the treatment of liver cirrhosis.
ISSN:0899-9007
1873-1244
DOI:10.1016/S0899-9007(96)00403-0