Weight gain over 4 months in schizophrenia patients: a comparison of olanzapine and risperidone

• Published in: Schizophrenia research 2001-04, Vol.49 (3), p.261-267
• Main Authors: Ganguli, Rohan, Brar, Jaspreet S., Ayrton, Zenia
• Format: Article
• Language: English
• Subjects: Adult; Antipsychotic Agents - adverse effects; Antipsychotic Agents - therapeutic use; Atypical antipsychotic; Benzodiazepines; Body Mass Index; Female; Follow-Up Studies; Humans; Male; Olanzapine; Pirenzepine - adverse effects; Pirenzepine - analogs & derivatives; Pirenzepine - therapeutic use; Risperidone; Risperidone - therapeutic use; Schizophrenia - drug therapy; Weight gain; Weight Gain - drug effects
• ISSN: 0920-9964; 1573-2509
• DOI: 10.1016/S0920-9964(00)00080-3

Weight gain frequently accompanies treatment with antipsychotics. In order to determine whether newer antipsychotic agents differ from each other with respect to weight gain, we compared two cohorts of patients with DSM-IV schizophrenia who had newly started treatment with either risperidone or olanzapine. After obtaining informed consent, data regarding body weight and height were culled from existing medical records of 100 patients (50 patients in each treatment group). Baseline body weight, close to the time of starting the new medication, and body mass index [BMI=weight (kg)/height (m) squared] were compared to the body weight and BMI following 4 months of treatment. There was no significant change in mean body weight or BMI in the group treated with risperidone (baseline weight=83.1 kg±20.5, follow-up=82.8 kg±19.9; matched pair t=0.66, P=n.s.; baseline BMI=29.6±9.4, follow-up=29.5±9.1; matched pair t=0.79, P=n.s.). However, in the group treated with olanzapine, there was a significant increase in both mean body weight and BMI (baseline weight=84.9 kg±25.0, follow-up=87.1 kg±25.1; matched pair t=4.62, P