Investigation into the enantioselective protonation of enolate Schiff bases with ( R)-pantolactone

The effect of several factors on the enantioselective protonation of the enolates of α-amino acid derivatives with ( R)-pantolactone were studied. The highest stereoselectivity (74–76% e.e.) was generally observed by associating lithium chloride with LHMDS and by using the optimum temperature for th...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron: asymmetry 2001-02, Vol.12 (1), p.49-52
Main Authors: Calmès, Monique, Glot, Christèle, Martinez, Jean
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of several factors on the enantioselective protonation of the enolates of α-amino acid derivatives with ( R)-pantolactone were studied. The highest stereoselectivity (74–76% e.e.) was generally observed by associating lithium chloride with LHMDS and by using the optimum temperature for the formation of the enolate. Graphic
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(00)00500-0