Enzymatic resolution of bicyclic 1,3-amino alcohols in organic media

N-Protected racemic di- exo- and di- endo-3-aminobicyclo[2.2.1]heptane-2-methanols and di- exo- and di- endo-3-aminobicyclo[2.2.1]hept-5-ene-2-methanols were resolved through lipase-catalysed O-acylation, using vinyl butyrate in organic solvents. Of the lipases screened most showed a preference for...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2001-03, Vol.12 (4), p.625-631
Main Authors: Kámán, Judit, Van der Eycken, Johan, Péter, Antal, Fülöp, Ferenc
Format: Article
Language:English
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Summary:N-Protected racemic di- exo- and di- endo-3-aminobicyclo[2.2.1]heptane-2-methanols and di- exo- and di- endo-3-aminobicyclo[2.2.1]hept-5-ene-2-methanols were resolved through lipase-catalysed O-acylation, using vinyl butyrate in organic solvents. Of the lipases screened most showed a preference for the (2 S)-enantiomer. N-Protected racemic di- exo- and di- endo-3-aminobicyclo[2.2.1]heptane-2-methanols and di- exo- and di- endo-3-aminobicyclo[2.2.1]hept-5-ene-2-methanols were resolved through lipase-catalysed O-acylation.
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(01)00093-3