Palladium-catalyzed asymmetric cyclocarbonylation of 2-(1-methylvinyl)anilines

The asymmetric cyclocarbonylation of 2-vinylanilines catalyzed by palladium with chiral phosphines was investigated. The reaction of 2-(1-methylvinyl)anilines using a catalyst system consisting of Pd(OAc) 2-2(−)-DIOP gave 3,4-dihydro-4-methyl-2(1H)-quinolin-2-ones in up to 54% enantiomeric excess. T...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 1997-07, Vol.8 (14), p.2307-2309
Main Authors: Okuro, Kazumi, Kai, Hidetomo, Alper, Howard
Format: Article
Language:English
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Summary:The asymmetric cyclocarbonylation of 2-vinylanilines catalyzed by palladium with chiral phosphines was investigated. The reaction of 2-(1-methylvinyl)anilines using a catalyst system consisting of Pd(OAc) 2-2(−)-DIOP gave 3,4-dihydro-4-methyl-2(1H)-quinolin-2-ones in up to 54% enantiomeric excess. The asymmetric cyclocarbonylation of 2-(1-methylvinyl)anilines proceeded by Pd(OAc) 2-2(−)-DIOP affording 3,4-dihydro-4-methyl-2(1H)-quinolin-2-ones in up to 54 % ee.
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(97)00263-2