A convenient synthesis of R-(−)-carnitine from R-(−)-epichlorohydrin

A convenient four-step synthesis of R-(−)-carnitine ( 1) is described from the reaction of R-(−)-epichlorohydrin ( 2) with vinylmagnesium bromide followed by formation of the ammonium salt 4 with trimethylamine and finally ozonolysis of the corresponding ammonium hydroxide 5. Graphic

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Bibliographic Details
Published in:Tetrahedron: asymmetry 1997-08, Vol.8 (16), p.2663-2665
Main Authors: Kabat, Marek M., Daniewski, Andrzej R., Burger, Walter
Format: Article
Language:English
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Description
Summary:A convenient four-step synthesis of R-(−)-carnitine ( 1) is described from the reaction of R-(−)-epichlorohydrin ( 2) with vinylmagnesium bromide followed by formation of the ammonium salt 4 with trimethylamine and finally ozonolysis of the corresponding ammonium hydroxide 5. Graphic
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(97)00324-8