Synthesis of reversed hydroxamic acids of indomethacin: dual inhibitors of cyclooxygenase and 5-lipoxygenase

Replacement of the carboxylic acid function of inodmethacin with reversed hydroxamic acids converted this selective cyclooxygenase (CO) inhibitor into dual inhibitors of CO and 5-lipoxygenase (5-LO). Replacement of the carboxylic acid function of indomethacin with reversed hydroxamic acids converted...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1992-12, Vol.2 (12), p.1655-1660
Main Authors: Kramer, James B., Boschelli, Diane H., Connor, David T., Kostlan, Catherine R., Flynn, Daniel L., Dyer, Richard D., Bornemeier, Dirk A., Kennedy, John A., Wright, Clifford D., Kuipers, Paul J.
Format: Article
Language:English
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Summary:Replacement of the carboxylic acid function of inodmethacin with reversed hydroxamic acids converted this selective cyclooxygenase (CO) inhibitor into dual inhibitors of CO and 5-lipoxygenase (5-LO). Replacement of the carboxylic acid function of indomethacin with reversed hydroxamic acids converted a selective cyclooxygenase (CO) inhibitor into dual inhibitors of CO and 5-lipoxygenase (5-LO).
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)80450-3