Synthesis and biological evaluation of N-(1-aziridino)-6-fluoro-quinolone-3-carboxylic acids

New racemic N-(1-aziridino)-6-fluoro-7-(4-methylpiperazin-1-yl)-4(1 H)-quinolone-3-carboxylic acids ( 9a-i) were synthesized and their antibacterial activities were tested against Gram-positive and Gram-negative micro-organisms. According to the MIC, all compounds studied are less active than Ciprof...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1996-07, Vol.6 (13), p.1507-1510
Main Authors: Bátori, Sándor, Tímári, Géza, Koczka, István, Hermecz, István
Format: Article
Language:English
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Summary:New racemic N-(1-aziridino)-6-fluoro-7-(4-methylpiperazin-1-yl)-4(1 H)-quinolone-3-carboxylic acids ( 9a-i) were synthesized and their antibacterial activities were tested against Gram-positive and Gram-negative micro-organisms. According to the MIC, all compounds studied are less active than Ciprofloxacin; two of them ( 9a,b) have similar activity as Nalidixic acid ( 1). New racemic N-(1-aziridino)-6-fluoro-7-(4-methylpiperazin-1-yl)-4(1 H)-quinolone-3-carboxylic acids ( 9a-i) were synthesized and their antibacterial activities were tested against Gram-positive and Gram-negative microorganisms.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(96)00259-4