Toll-like receptors, a double-edged sword in immunity to malaria

Toll-like receptors （TLRs） are a central component of innate immune system and play a major role as the initiator of the innate immune responses to defend against bacteria, viruses, parasite and other pathogens. During malaria infection, TLRs signaling pathways are initialed with the recognition of...

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Bibliographic Details
Published in:Journal of Medical Colleges of PLA 2009-04, Vol.24 (2), p.118-124
Main Authors: Jide, Chen, Ying, He, Wenyue, Xu, Fusheng, Huang
Format: Article
Language:English
Subjects:
Innate immunity
Malaria
Plasmodium
Toll-like receptors
Toll样受体
免疫反应
免疫系统
受体信号通路
寄生虫
抗疟疾药物
疟疾感染
病原相关分子模式
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Summary:Toll-like receptors （TLRs） are a central component of innate immune system and play a major role as the initiator of the innate immune responses to defend against bacteria, viruses, parasite and other pathogens. During malaria infection, TLRs signaling pathways are initialed with the recognition of Plasmodium glycosylphosphatidylinositols （GPI） and hemozoin as pathogen-associated molecular patterns （PAMPs）. And then, activation of TLRs signaling induces specific biological responses against malaria parasites invasion, However, TLRs are also involved in malaria pathogenesis and enhancement of immune tolerance and evasion for malaria infection. Moreover, malaria parasites regulate selectively TLRs expression on immune cells. Thus, these evidences indicated that TLRs have contrary roles on malaria infection. Understanding the complicated roles of TLRs on malaria infection will contribute us to design more effective anti-malaria drugs or vaccines
ISSN:1000-1948
DOI:10.1016/S1000-1948(09)60027-7