Static and ELF magnetic fields enhance the in vivo anti-tumor efficacy of cis-platin against lewis lung carcinoma, but not of cyclophosphamide against B16 melanotic melanoma

Previous works showed that exposure to static and extremely low frequency (ELF) magnetic fields (MF) over 3 mT slows down the growth kinetics of human tumors engrafted s.c. in immunodeficient mice, reducing their metastatizing power and prolonging mouse survival. In the experiments reported here, im...

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Bibliographic Details
Published in:Pharmacological research 2003-07, Vol.48 (1), p.83-90
Main Authors: Tofani, S, Barone, D, Berardelli, M, Berno, E, Cintorino, M, Foglia, L, Ossola, P, Ronchetto, F, Toso, E, Eandi, M
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - metabolism
Antineoplastic Agents - therapeutic use
B16 melanotic melanoma
Carcinoma, Lewis Lung - drug therapy
Carcinoma, Lewis Lung - mortality
Carcinoma, Lewis Lung - therapy
Cis-platin
Cisplatin - metabolism
Cisplatin - therapeutic use
Combined Modality Therapy
Cyclophasphamide
Cyclophosphamide - therapeutic use
Disease Models, Animal
Electromagnetic Fields
Free Radicals - metabolism
Lewis lung carcinoma
Lung Neoplasms - drug therapy
Lung Neoplasms - mortality
Lung Neoplasms - therapy
Magnetic fields
Melanoma, Experimental - drug therapy
Melanoma, Experimental - mortality
Melanoma, Experimental - therapy
Mice
Mice, Inbred A
Mice, Inbred C57BL
Reactive Oxygen Species - metabolism
Skin Neoplasms - drug therapy
Skin Neoplasms - mortality
Skin Neoplasms - therapy
Static Electricity
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Summary:Previous works showed that exposure to static and extremely low frequency (ELF) magnetic fields (MF) over 3 mT slows down the growth kinetics of human tumors engrafted s.c. in immunodeficient mice, reducing their metastatizing power and prolonging mouse survival. In the experiments reported here, immunocompetent mice bearing murine Lewis Lung carcinomas (LLCs) or B16 melanotic melanomas were exposed to MF and treated respectively with two commonly used anti-cancer drugs: cis-diamminedichloroplatinum ( cis-platin) and N, N-bis (2-chloroethyl)tetra-hydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide (cyclophosphamide). The experiment endpoint was survival time. The survival time of mice treated with cis-platin (3 mg/kg i.p.) and exposed to MF was significantly ( P
ISSN:1043-6618
1096-1186
DOI:10.1016/S1043-6618(03)00062-8