PP11.6 – 2858: ADHD predominantly inattentive subtype, interictal epileptiform discharges and use of methylphenidate for ADHD

• Published in: European journal of paediatric neurology 2015-05, Vol.19, p.S75-S75
• Main Authors: Socanski, D, Herigstad, A, Beneventi, H, Einarsdottir, S
• Format: Article
• Language: English
• Subjects: Neurology; Pediatrics
• ISSN: 1090-3798; 1532-2130
• DOI: 10.1016/S1090-3798(15)30249-X

Objective Interictal epileptiform discharges (IED) occur more often in children with attention deficit/hyperactivity disorder predominantly inattentive subtype (ADHD-I), and may contribute to the occurrence of ADHD symptoms in some cases. The aim of the present study was to investigate whether IED in children with ADHD-I influence the use of methylphenidate (MPH) during one year follow-up. Methods 517 children diagnosed with ADHD (82% male), age 5–14 years, performed routine awake EEG at ADHD assessment over 6 years period. 39 had EEG with IED. The group with IED was compared to an age and gender matched control group without IED. The groups showed no differences in using of MPH during one year follow-up. This study examined whether IED influence the use of MPH in a subgroup with ADHD-I with and without IED. Outcome measures were: initial positive response to MPH after 4–6 weeks titration, and the use of MPH at one-year follow-up. Results ADHD-I was diagnosed in 22 of 78 cases. 16 of 22 had IED, and 4 had previous history of epilepsy. Of the 16 cases with IED, 14 (87.5%) hade initial positive response to MPH, and 13 (81.3%) used MPH at one year follow-up. ADHD-I without IED was found in 6. Of the 6 cases with ADHD-I without IED, 5 (83.3%) had positive initial response to MPH, and 5 (83.3%) used MPH at one year follow-up. There was no statistic difference between the groups in using of MPH. Conclusion There is a higher occurrence of IED in ADHD-I. This study suggested that IED occurrence in ADHD-I does not influence the use of MPH during one year follow-up.