Biotransformations of organosilicon compounds: enantioselective reduction of acyl silanes by means of baker's yeast

The enantioselective reduction of acyl silanes has been performed employing baker's yeast (BY) in fermenting conditions: a series of substrates of different structure was investigated, showing that the reactivity as well as the level of enentioselectivity depends on the steric bulk of the subst...

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Bibliographic Details
Published in:Journal of molecular catalysis. B, Enzymatic Enzymatic, 2001-01, Vol.11 (4-6), p.279-285
Main Author: Zani, Paolo
Format: Article
Language:English
Subjects:
Acyl silanes
Asymmetric synthesis
Baker's yeast
Bioconversions. Hemisynthesis
Biological and medical sciences
Bioreduction
Biotechnology
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
α-Hydroxy silanes
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Summary:The enantioselective reduction of acyl silanes has been performed employing baker's yeast (BY) in fermenting conditions: a series of substrates of different structure was investigated, showing that the reactivity as well as the level of enentioselectivity depends on the steric bulk of the substituents on the acyl silane. The products α-hydroxy silanes were obtained with chemical and optical yields over 90% in the most favourable cases.
ISSN:1381-1177
1873-3158
DOI:10.1016/S1381-1177(00)00052-7