Electrochemistry and Bioactivity Relationship of Pt (IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N, N'-Diacetate-Type Ligands

Pt (IV) complexes with ethylenediamine-N, N'-diacetate-type ligands exhibit strong antitumor activity towards various cancer cell lines. In order to explain their complete mechanisms of action, we examined bioreductive character of eight compounds in total using cyclic voltammetry, differential...

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Bibliographic Details
Published in:International journal of electrochemical science 2013-06, Vol.8 (6), p.8433-8441
Main Authors: Mihajlović, Ljiljana E., Stanković, Dalibor, Poljarević, Jelena, Manojlović, Dragan, Sabo, Tibor J., Grgurić-Šipka, Sanja
Format: Article
Language:English
Subjects:
anticancer
platinum (IV)
reduction potential
voltammetry
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Summary:Pt (IV) complexes with ethylenediamine-N, N'-diacetate-type ligands exhibit strong antitumor activity towards various cancer cell lines. In order to explain their complete mechanisms of action, we examined bioreductive character of eight compounds in total using cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy. Recorded voltammograms of all Pt (IV) complexes with methyl, ethyl, n-propyl and n-butyl esters of (S, S)-ethylenediamine-N, N'-di-2-(3-cyclohexyl) propanoic acid confirmed two successive one-electron transfer steps followed by the loss of the corresponding axial ligands. The redox potential values for Pt (IV) complexes were in the range of -0.92 V
ISSN:1452-3981
1452-3981
DOI:10.1016/S1452-3981(23)12900-2