WS09.6 The effect of a 12-month adherence intervention, “CF My Way“, on medication possession, clinical outcomes and quality of life in CF adolescents and young adults

• Published in: Journal of cystic fibrosis 2015-06, Vol.14, p.S18-S18
• Main Authors: Landau, E, Kalamaro, V, Taizi, T, Kadosh, D, Mantin, H, Mussaffi, H, Blau, H
• Format: Article
• Language: English
• Subjects: Pulmonary/Respiratory
• ISSN: 1569-1993; 1873-5010
• DOI: 10.1016/S1569-1993(15)30057-6

Background People with CF require many medications daily. Adolescents and young adults often adhere poorly and find the burden of treatment a challenge. The “CF My Way” program was developed by Alexandra Quittner to increase individual responsibility in treatment regimens. Objectives To apply the “CF My Way” program over 12 months and assess its impact on medication possession, clinical outcomes and quality of life. Methods 16 CF patients, 10 male, aged 24.1±2.5 y (SD 2.48) participated in a pre-test/post-test 12mth intervention with 4 meetings focused on individualized barriers to adherence and ‘brainstorming’ for solutions. We compared adherence using medication possession ratio (MPR) from national health fund data over 12mths pre and post intervention, change in FEV1 (%predicted) and BMI; quality of life using the CFQ(R) questionnaire; and physiotherapy frequency and duration. Results MPR as % of prescribed medicines for colistimethate sodium inhalations increased from 21% (0–100) to 56% (0–100), median (range), p = 0.04 and for tobramycin inhalations increased from 20% (0–100) to 33.3% (25–100), p = 0.03; BMI SDS rose from −0.37 (0.54) to −0.21 (0.54), p = 0.05. FEV1 % predicted, physiotherapy frequency and quality of life did not change. Sport, inhalation therapy and dietary uptake were the most frequently chosen barriers for intervention to work on. Conclusion In this pilot study, clinical intervention can increase adherence to medical treatments, particularly when relating to particular needs and barriers of each patient.