8-Hydroxy-2'-Deoxyguanosine and Lipid Peroxidation in Patients With Heart Failure

• Published in: Revista española de cardiologia 2006-11, Vol.59 (11), p.1140-1145
• Main Authors: Rivera, Miguel, Roselló-Lletí, Esther, García de Burgos, Fernando, Bertomeu, Vicente, Payá, Rafael, Cortés, Raquel, Martínez-Dolz, Luis, Jordán, Alejandro, Pérez-Boscá, Jose L., Salvador, Antonio, Marín, Francisco, Sogorb, Francisco, Valero, Ricardo, Miró, Vicente, Portolés, Manuel
• Format: Article
• Language: eng ; spa
• Subjects: Case-Control Studies; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - blood; Estrés oxidativo; Female; Free radicals; Heart failure; Heart Failure - blood; Heart Failure - metabolism; Humans; Insuficiencia cardiaca; Lipid Peroxidation; Male; Middle Aged; Oxidative stress; Radicales libres
• ISSN: 1885-5857; 0300-8932; 1885-5857
• DOI: 10.1016/S1885-5857(07)60063-2

Heart failure is associated with increased free radical production, which leads to a state of oxidative stress. Known markers of oxidative stress include 8-hydroxy-2'-deoxyguanosine, which reflects oxidative damage to DNA, and lipid peroxidation, which can be used to quantify damage to lipid-rich structures. The aims of this study were to compare 8-hydroxy-2'-deoxyguanosine and lipid peroxidation levels in heart failure patients and healthy subjects and to assess how these levels are influenced by heart failure etiology. The study included 78 patients (57 male, age 64 [14] years) with heart failure and 12 control subjects. Patients completed a questionnaire and were graded according to the New York Heart Association classification. Doppler echocardiography was performed and blood samples were obtained. 8-hydroxy-2'-deoxyguanosine and lipid peroxidation levels were determined. Significant differences were observed between patients and control subjects in 8-hydroxy-2'-deoxyguanosine and lipid peroxidation levels, at 0.34 (0.54) ng/mL vs 0.04 (0.07) ng/mL ( P