AML-591 Comprehensive Geriatric Assessment and Clinical Outcomes of Acute Myeloid Leukemia Patients in a Latin American University Hospital

• Published in: Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2023-09, Vol.23, p.S315-S316
• Main Authors: Porras, Cristian, Cadena, Miguel, Ochoa, Miguel, Peña, Ángela, Salazar, Luis, Rosales, Manuel, Luna, María, Sossa, Claudia
• Format: Article
• Language: English
• Subjects: acute myeloid leukemia; AML; comprehensive geriatric assessment; Latin America
• ISSN: 2152-2650; 2152-2669
• DOI: 10.1016/S2152-2650(23)01087-X

In patients with acute myeloid leukemia (AML), comprehensive geriatric assessment (CGA) has been shown to provide valuable information for selecting the most appropriate chemotherapy regimen. In Latin America and Colombia, there are no studies evaluating the possible associations of CGA with outcomes in patients with AML. To evaluate the association between CGA and clinical outcomes in patients with AML in a university hospital in Colombia. Retrospective cohort study conducted between June 1, 2013, and December 31, 2021. All patients were followed for at least one year after AML diagnosis. Referral center caring for adult patients with AML. Patients aged 60 years or older (60+) with a diagnosis of AML and CGA were included. Patients in the study underwent CGA. Univariate and bivariate analyses were performed to describe the study population and determine the possible association of the CGA scales with outcome measures. Overall survival, event-free survival, toxicity, and complete remission after induction chemotherapy. Seventy-seven patients 60+ were included. The median age was 71 years (IQR:64–79), 53.2% were men, and 55.8% (n=43) had ECOG < 2. In line with the Frail Scale, 54.5% (n=42) and 32.5% (n=25%) were pre-frail and frail, respectively. Pre-frailty and frailty according to the Frail Scale were associated with shorter overall survival (HR 1.6, 95%CI 1.05-2.55). Mild dependence according to the Lawton scale reduced the probability of complete remission after induction chemotherapy by 56% (RR 0.4, 95%CI 0.20-0.96). CGA was not associated with event-free survival or toxicity. Frailty or pre-frailty according to the Frail scale in adults 60+ with a diagnosis of AML was associated with a shorter overall survival at one year. Furthermore, this is the first analytical observational study in the literature to describe a statistically significant association between the Frail score and overall survival in elderly patients with a diagnosis of AML.