MM-228 A Different Point of View: Facial Paralysis as a Manifestation of AL Amyloidosis

Amyloid neuropathy occurs only in systemic amyloidosis. It is progressive and may begin at a different time of disease. The typical pattern is symmetrical, and limb predominant. We here reported an AL amyloidosis patient with severe cranial neuropathy manifested as facial paralysis. A 56-year-old ma...

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Bibliographic Details
Published in:Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2023-09, Vol.23, p.S482-S483
Main Authors: Koruk, Kıvanç, Fidan, Funda, Aslanlı, Azize, Erdem, Simge, Beşışık, Sevgi Kalayoğlu
Format: Article
Language:English
Subjects:
AL amyloidosis
amyloid neuropathy
cranial neuropathy
systemic amyloidosis
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Summary:Amyloid neuropathy occurs only in systemic amyloidosis. It is progressive and may begin at a different time of disease. The typical pattern is symmetrical, and limb predominant. We here reported an AL amyloidosis patient with severe cranial neuropathy manifested as facial paralysis. A 56-year-old man was evaluated for anemia and proteinuria. He had monoclonal gammopathy IgG, lambda type with a serum creatinine level increase. The bone marrow clonal plasma cell ratio was less than 10%. Kidney function deteriorated and proteinuria turned to a massive degree. A kidney biopsy was decided. Congo-red positivity with lambda deposits in the glomeruli and arteriolar vessels was detected. He had facial paralysis and heart failure with high serum NT-pro-BNP levels. A diagnosis of AL amyloidosis with renal, cardiac, and cranial nerve involvement was made. AL amyloidosis-related cranial neuropathy is extremely rare but should be in mind along with other typical manifestations.
ISSN:2152-2650
2152-2669
DOI:10.1016/S2152-2650(23)01421-0