Investigation of the three-dimensional orientation of mineralized collagen fibrils in human lamellar bone using synchrotron X-ray phase nano-tomography

We investigate the three-dimensional (3-D) organization of mineralized collagen fibrils in human cortical bone based on synchrotron X-ray phase nano-tomography images. In lamellar bone the collagen fibrils are assumed to have a plywood-like arrangement, but due to experimental limitations the 3-D fi...

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Bibliographic Details
Published in:Acta biomaterialia 2013-09, Vol.9 (9), p.8118-8127
Main Authors: Varga, Peter, Pacureanu, Alexandra, Langer, Max, Suhonen, Heikki, Hesse, Bernhard, Grimal, Quentin, Cloetens, Peter, Raum, Kay, Peyrin, Françoise
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
analysis
biocompatible materials
chemistry
collagen
Female
Femur
Femur - chemistry
Femur - diagnostic imaging
Femur - ultrastructure
Fibrillar Collagens
Fibrillar Collagens - ultrastructure
Humans
image analysis
Imaging, Three-Dimensional
Imaging, Three-Dimensional - methods
In Vitro Techniques
Lamellar bone
methods
mineralization
Mineralized collagen fibril
Minerals
Minerals - analysis
Osteon
Plywood arrangement
Protein Conformation
radiography
structure-activity relationships
Synchrotrons
tomography
Tomography, X-Ray
Tomography, X-Ray - methods
ultrastructure
X-radiation
X-ray phase nano-tomography
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