Initial experience with abiraterone acetate in patients with castration-resistant prostate cancer

• Published in: Actas urológicas españolas (English ed.) 2014-06, Vol.38 (5), p.339-345
• Main Authors: Beardo-Villar, P, Ledo-Cepero, M.J, Gavira-Moreno, R, Soto-Delgado, M, Soto-Villalba, J, Alvarez-Ossorio, J.L, Juárez-Soto, A
• Format: Article
• Language: English
• Subjects: 17α-hidroxilasa; 17α-Hydroxylase; Abiraterona acetato; Abiraterone acetate; CYP17; Cáncer de próstata resistente a la castración; Metastatic castration-resistant prostate cancer; New hormonal therapies; Nuevas terapias hormonales; Secondary hormonal therapy; Terapia hormonal secundaria; Urology
• ISSN: 2173-5786; 2173-5786
• DOI: 10.1016/j.acuroe.2014.02.011

Abstract Objective To describe the results obtained in 25 men with metastatic castration-resistant prostate cancer (MCRPC) treated with abiraterone (AA). A comparative analysis of abiraterone effectiveness and safety between our results and data published in the literature was conducted. Materials and method Bi-institutional prospective analysis of 25 consecutive patients with MCRPC undergoing treatment with abiraterone, with a mean follow-up 7.9 (3–15) months was carried out. Treatment effectiveness and safety analyses regarding baseline characteristics of patients (age, prior treatments, basal PSA, performance status, pain, and metastasis) were conducted. Results At 13.6 months of follow-up, the overall survival is 80% (CI 95%: 11.8–15.4). Clinical and radiological-free progression survival is 9.5 ± 1 months (CI 95%: 7.7–11.3) and biochemical response is 6.8 ± 1 months (CI 95%: 5–8.7). Only the treatment with chemotherapy impaired significantly the response time to AA [6.4 months for radiological-free progression survival (CI 95%: 4.2–8.6) and 4.3 months for biochemical-free progression survival (CI 95%: 2.6–6)]. The incidence of adverse drug events was 36%; all of them were of grade 1–2/4 and, in no case, suspension or reduction of the dose of AA was needed. Conclusions The treatment with AA has been effective in our series, with a tolerability considerably higher than what other studies published.