Immunohistochemical profiling is useful to distinguish oral neural benign neoplasms

The most common oral neurogenic lesions are traumatic neuroma, neurilemmoma, and neurofibroma. They share clinical and histological features, but have a different prognosis and treatment. Our aim was to use a small panel of immunohistochemistry antibodies to distinguish among them. Eight cases of tr...

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Bibliographic Details
Published in:Journal of oral and maxillofacial surgery, medicine, and pathology medicine, and pathology, 2018-01, Vol.30 (1), p.60-66
Main Authors: Nagata, Gabriela, Passador-Santos, Fabrício, Adachi, Patrícia, de Sousa, Suzana Cantanhede Machado, Trierveiler, Marília
Format: Article
Language:English
Subjects:
Benign neural neoplasms
Immunohistochemistry
Neurilemmoma
Neurofibroma
Traumatic neuroma
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Summary:The most common oral neurogenic lesions are traumatic neuroma, neurilemmoma, and neurofibroma. They share clinical and histological features, but have a different prognosis and treatment. Our aim was to use a small panel of immunohistochemistry antibodies to distinguish among them. Eight cases of traumatic neuroma, 9 cases of neurilemmoma, and 11 cases of neurofibroma were selected and stained with primary antibodies against S-100 protein, laminin, and epithelial membrane antigen (EMA) using the streptavidin-biotin-peroxidase method of immunohistochemistry. The S-100 protein was positive in the endoneurium of traumatic neuroma, Schwann cells, and Verocay bodies of the neurilemmomas and revealed a variable number of positive cells amongst spindle-shaped cells that compose neurofibromas. Laminin was positive in the endoneurium and in the perineurium of traumatic neuromas. In neurilemmomas, all neoplasic cells and the capsule were positive for laminin. For neurofibromas, laminin positivity followed the patterns observed for S-100 protein. EMA was positive in the perineurium of traumatic neuroma and in the capsule of neurilemmomas. Most cases of neurofibroma were completely negative for EMA, but three cases showed rare, scattered positive cells. The use of this small immunohistochemical panel to evaluate the presence and localization of S-100 protein, laminin, and EMA can help to distinguish among these three lesions and provide a more specific diagnosis. Consequently, this will provide a better prognosis for patients.
ISSN:2212-5558
2212-5566
DOI:10.1016/j.ajoms.2017.06.013