Sedentary Behavior and Adiposity-Associated Inflammation

• Published in: American journal of preventive medicine 2012, Vol.42 (1), p.8-13
• Main Authors: Allison, Matthew A., MD, MPH, Jensky, Nicole E., PhD, Marshall, Simon J., PhD, Bertoni, Alain G., MD, MPH, Cushman, Mary, MD
• Format: Article
• Language: English
• Subjects: Internal Medicine
• ISSN: 0749-3797; 1873-2607
• DOI: 10.1016/j.amepre.2011.09.023

Background Sedentary behavior is associated with adiposity and cardiometabolic risk. Purpose To determine the associations between sedentary behavior and measures of adiposity-associated inflammation. Methods Between 2002 and 2005, a total of 1543 Multi-Ethnic Study of Atherosclerosis participants completed detailed health history questionnaires, underwent physical measurements, and had blood assayed for adiponectin, leptin, tumor necrosis factor–alpha (TNF-α) and resistin. Analyses included linear regression completed in 2010. The mean age was 64.3 years and nearly 50% were female. Forty-one percent were non-Hispanic white, 24% Hispanic-American, 20% African-American, and 14% Chinese-American. Results In linear regression analyses and with adjustment for age, gender, ethnicity, education, BMI, smoking, alcohol consumption, hypertension, diabetes mellitus, dyslipidemia, hormone therapy and waist circumference, sedentary behavior was associated with higher natural log (“ln”) of leptin and ln TNF-α but a lower ln adiponectin-to-leptin ratio (β=0.07, β=0.03 and –0.07, p