Bacterial activation of surface-tethered antimicrobial peptides for the facile construction of a surface with self-defense

In this study, a charge-conversion mechanism was introduced into the design of a bacteria-responsive antibacterial surface. The antibacterial surface was facilely constructed via surface tethering of antimicrobial peptides (AMPs) to solid supports and subsequently integrating charge-conversion moiet...

Full description

Saved in:
Bibliographic Details
Published in:Applied surface science 2019-12, Vol.497, p.143480, Article 143480
Main Authors: Zhang, Jing, Zhou, Rongtao, Wang, Han, Jiang, Xiuyun, Wang, Huiyan, Yan, Shunjie, Yin, Jinghua, Luan, Shifang
Format: Article
Language:English
Subjects:
Bacteria-responsive
Cationic antimicrobial peptide
Charge-reversal
Self-defensive antibacterial
Surface tethering
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, a charge-conversion mechanism was introduced into the design of a bacteria-responsive antibacterial surface. The antibacterial surface was facilely constructed via surface tethering of antimicrobial peptides (AMPs) to solid supports and subsequently integrating charge-conversion moieties into the peptide structure. The resulting zwitterionic structure of the AMPs rendered the antibacterial surface biocompatible under normal physiological conditions. Importantly, the surface exhibited self-defense properties specifically against pathogenic bacteria; the toxicity of AMPs was activated in bacterially induced acidic environments. Unlike previously described self-defense systems that utilize an antimicrobial release mechanism, this antibacterial surface exerts its bactericidal effects by diminishing the nonbactericidal masking moieties and activating the surface-tethered AMPs to avoid the undesirable toxic effects caused by planktonic AMPs. In contrast to the prevailing passive switchable antibacterial surfaces, our surface uses a unique self-adaptive zwitterionic-to-cationic transition mechanism to inhibit the development of bacterial infections. •A charge-conversion mechanism is introduced into the antibacterial surface design.•Bacteria-responsive antibacterial surface is biocompatible in vitro and in vivo.•Surface tethered MLT can be activated in bacterially induced acidic environments.•Self-adaptive zwitterionic-to-cationic transition to combat bacterial infections
ISSN:0169-4332
1873-5584
DOI:10.1016/j.apsusc.2019.07.222