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Enhanced endothelial cell activity induced by incorporation of nano-thick tantalum layer in artificial vascular grafts
[Display omitted] •Ta-implanted surface layer on ePTFE was fabricated via sputtering-based plasma immersion ion implantation technique.•Ta-implanted ePTFE exhibited excellent adhesion stability and an extremely low level of Ta ions released from the surface.•Surface properties of the Ta-implanted eP...
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Published in: | Applied surface science 2020-04, Vol.508, p.144801, Article 144801 |
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Main Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | [Display omitted]
•Ta-implanted surface layer on ePTFE was fabricated via sputtering-based plasma immersion ion implantation technique.•Ta-implanted ePTFE exhibited excellent adhesion stability and an extremely low level of Ta ions released from the surface.•Surface properties of the Ta-implanted ePTFE were highly favorable for endothelial cell adherence and growth.•Ta-implanted ePTFE also possessed antithrombogenic properties, suppressing platelet adhesion and activation on the surface.
Expanded polytetrafluoroethylene (ePTFE) has been successfully used as an artificial vascular graft material owing to its unique merits of fibrous structure, chemical stability, physical robustness, and nontoxicity. However, its insufficient endothelial cell affinity arising from its highly hydrophobic surface nature induces early thrombus formation and development of neointimal hyperplasia, leading to poor long-term patency rates. In this study, we demonstrate a novel rapid surface modification technique, termed as sputtering-based plasma immersion ion implantation (S-PIII), to elicit favorable vascular responses on the ePTFE surface. This technique enables rapid ion implantation of biologically compatible tantalum (Ta) into ePTFE surfaces, generating a nano-thick Ta-rich surface layer ( |
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ISSN: | 0169-4332 1873-5584 |
DOI: | 10.1016/j.apsusc.2019.144801 |