Compactibility improvement of metformin hydrochloride by crystallization technique

[Display omitted] ► Metformin hydrochloride was crystallized in the presence of polyvinlypyrrolidone. ► Treated metformin was directly compressible. ► FTIR and DSC studies showed no physico-chemical changes in metformin. The objectives of the present study were to address the issues of poor flow and...

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Bibliographic Details
Published in:Advanced powder technology : the international journal of the Society of Powder Technology, Japan Japan, 2012-11, Vol.23 (6), p.814-823
Main Authors: Barot, Bhavesh S., Parejiya, Punit B., Patel, Tushar M., Parikh, Rajesh K., Gohel, Mukesh C.
Format: Article
Language:English
Subjects:
Crystallization
Direct compression
Heckel analysis
Kawakita analysis
Metformin
Response surface analysis
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Summary:[Display omitted] ► Metformin hydrochloride was crystallized in the presence of polyvinlypyrrolidone. ► Treated metformin was directly compressible. ► FTIR and DSC studies showed no physico-chemical changes in metformin. The objectives of the present study were to address the issues of poor flow and inadequate compressibility of metformin HCl by adopting particle engineering technique. Metformin HCl was crystallized in the presence of polyvinylpyrrolidone (PVP K30). A 32 full factorial design (FFD) was employed for optimization of the processing parameters. Percentage PVP K30 in solution (X1) and crystallization time (X2) were chosen as the independent variables. Percentage yield (Y1), Carr’s index (Y2) and tensile strength of compacts (Y3) were selected as dependent variables. Mathematical models were evolved and contour plots were drawn. Metformin HCl particles crystallized in the presence of 2% PVP K30 with crystallization time of four hours (CryMet), showed impressive improvement in flow property, compressibility as well as compactibility as compared to untreated metformin HCl (XMet). The derived compaction parameters ‘a’, ‘1/b’ and ‘Py’, obtained using Kawakita and Heckel equations were 0.369, 15.34 and 198.54MPa for XMet; and 0.249, 11.05 and 143.33MPa for CryMet respectively. Compressibility evaluation of the samples revealed poor compressibility of XMet while CryMet was directly compressible. DSC and FTIR experiments showed that CryMet particles did not undergo chemical modifications during crystallization.
ISSN:0921-8831
1568-5527
DOI:10.1016/j.apt.2011.11.002