Spectrophotometric study of stability constants of cimetidine–Ni(II) complex at different temperatures

Cimetidine, a histamine H2-receptor, has a structure which enables it to act as a chelating agent. The formation of nickel(II) complex with cimetidine has been studied spectrophotometrically at an absorption maximum of 622nm at different temperatures. The data show that nickel(II) and cimetidine com...

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Bibliographic Details
Published in:Arabian journal of chemistry 2012-07, Vol.5 (3), p.309-314
Main Authors: Tirmizi, Syed Ahmad, Wattoo, Feroza Hamid, Wattoo, Muhammad Hamid Sarwar, Sarwar, Saadia, Memon, Allah Nawaz, Ghangro, Allah Bux
Format: Article
Language:English
Subjects:
Cimetidine
Nickel
Spectrophotometry
Stability constant
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Summary:Cimetidine, a histamine H2-receptor, has a structure which enables it to act as a chelating agent. The formation of nickel(II) complex with cimetidine has been studied spectrophotometrically at an absorption maximum of 622nm at different temperatures. The data show that nickel(II) and cimetidine combine in the molar ratio of 1:2. The stability constants of the complex were calculated to be 1.40–2.4×108 by continuous variation method and 1.24–2.4×108 by mole ratio method at 25 and 40°C, respectively. The immediately formed complex shows stability with respect to time and temperature.
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2010.09.009