Premixed Antibiotic Bone Cement

Abstract After Food and Drug Administration (FDA) approval of premixed antibiotic bone cements (polymethylmethacrylate [PMMA]), these products are being used with increasing frequency during revision and primary hip and knee arthroplasties. To date, no studies have compared the antimicrobial efficac...

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Bibliographic Details
Published in:The Journal of arthroplasty 2008, Vol.23 (6), p.110-114
Main Authors: Squire, Matthew W., MD, Ludwig, Brian J., MD, Thompson, Jonathan R., BS, Jagodzinski, Jason, BS, Hall, Derek, BS, Andes, David, MD
Format: Article
Language:English
Subjects:
Orthopedics
polymethylmethacrylate
premixed antibiotic bone cement
total hip anthroplasty
total knee arthroplasty
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Summary:Abstract After Food and Drug Administration (FDA) approval of premixed antibiotic bone cements (polymethylmethacrylate [PMMA]), these products are being used with increasing frequency during revision and primary hip and knee arthroplasties. To date, no studies have compared the antimicrobial efficacy of more than 2 products directly. Using a 7-day modified Kirby-Bauer assay, we assessed the in vitro antibacterial properties of 5 FDA-approved, commercially available antibiotic PMMAs. Significant differences in antimicrobial activity were noted among the antibiotic PMMA products included in this investigation. Antibacterial activity of all products tested was greatest on day 1 and rapidly diminished thereafter. Results of this investigation suggest that the antibacterial efficacies of premixed antibiotic PMMA products are not equivalent.
ISSN:0883-5403
1532-8406
DOI:10.1016/j.arth.2008.03.014