Communication between mitochondria and nucleus: Putative role for VDAC in reduction/oxidation mechanism

Voltage dependent anion channel (VDAC) was identified in 1976 and since that time has been extensively studied. It is well known that VDAC transports metabolites across the outer mitochondrial membrane. The simple transport function is indispensable for proper mitochondria functions and, consequentl...

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Published in:Biochimica et biophysica acta 2010-06, Vol.1797 (6-7), p.1276-1280
Main Authors: Galganska, Hanna, Karachitos, Andonis, Wojtkowska, Malgorzata, Stobienia, Olgierd, Budzinska, Malgorzata, Kmita, Hanna
Format: Article
Language:English
Subjects:
Cell Nucleus - metabolism
Cytosol - metabolism
Cytosol redox state
Expression of mitochondrial proteins
Mitochondria - metabolism
Mitochondrial Proteins - metabolism
Models, Biological
Oxidation-Reduction
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - metabolism
Signal Transduction
Superoxide anion
Superoxide Dismutase - metabolism
VDAC
Voltage-Dependent Anion Channels - metabolism
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Summary:Voltage dependent anion channel (VDAC) was identified in 1976 and since that time has been extensively studied. It is well known that VDAC transports metabolites across the outer mitochondrial membrane. The simple transport function is indispensable for proper mitochondria functions and, consequently for cell activity, and makes VDAC crucial for a range of cellular processes including ATP rationing, Ca2+ homeostasis and apoptosis execution. Here, we review recent data obtained for Saccharomyces cerevisiae cells used as a model system concerning the putative role of VDAC in communication between mitochondria and the nucleus. The S. cerevisiae VDAC isoform known as VDAC1 (termed here YVDAC) mediates the cytosol reduction/oxidation (redox) state that contributes to regulation of expression and activity of cellular proteins including proteins that participate in protein import into mitochondria and antioxidant enzymes. Simultaneously, copper-and-zinc-containing superoxide dismutase (CuZnSOD) plays an important role in controlling YVDAC activity and expression levels. Thus, it is proposed that VDAC constitutes an important component of a regulatory mechanism based on the cytosol redox state.
ISSN:0005-2728
0006-3002
1879-2650
DOI:10.1016/j.bbabio.2010.02.004