Mitochondrial DNA maintenance defects

The maintenance of mitochondrial DNA (mtDNA) depends on a number of nuclear gene-encoded proteins including a battery of enzymes forming the replisome needed to synthesize mtDNA. These enzymes need to be in balanced quantities to function properly that is in part achieved by exchanging intramitochon...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Molecular basis of disease 2017-06, Vol.1863 (6), p.1539-1555
Main Authors: El-Hattab, Ayman W., Craigen, William J., Scaglia, Fernando
Format: Article
Language:English
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