162. Cytomegalovirus serostatus and antibody response to influenza vaccination in older adults

• Published in: Brain, behavior, and immunity behavior, and immunity, 2014-09, Vol.40, p.e47-e47
• Main Authors: Segerstrom, S.C, Greenberg, R.N
• Format: Article
• Language: English
• Subjects: Allergy and Immunology; Psychiatry
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2014.06.182

Cytomegalovirus (CMV) has been implicated as a factor in immunosenescence, including poor antibody response to influenza vaccination. The present investigation tested this implication in adults aged 60–91 ( N = 98; 70% CMV seropositive) vaccinated for up to 5 years ( n = 325 person-years). Interactions between CMV serostatus and chronological age, another cause of immunosenescence, and use of beta-blockers, a potential protection against latent virus reactivation, were tested. Peak antibody, corrected for baseline, and spring antibody persistence, corrected for peak, were assessed. In multi-level models with years at Level 1 and people at Level 2, there was no main effect of CMV serostatus on peak antibody, but there was a 3-way interaction between CMV serostatus, age, and beta-blockers (interaction: γ = −.14, SE = .06, p < .03). In this interaction, age was negatively associated with peak antibody, but only among adults who were CMV + and taking beta-blockers (simple age slope: γ = − .08, SE=.02, p