Replication and reproducibility issues in the relationship between C-reactive protein and depression: A systematic review and focused meta-analysis

•Inflammation has been identified as a biological process relevant in depression.•C-reactive protein is a biomarker of inflammation.•Methodological inconsistences are widespread in the field.•Methodological inconsistences in the literature hinder reproducibility.•Methodologically rigorous studies ar...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2018-10, Vol.73, p.85-114
Main Authors: Horn, Sarah R., Long, Madison M., Nelson, Benjamin W., Allen, Nicholas B., Fisher, Philip A., Byrne, Michelle L.
Format: Article
Language:English
Subjects:
Biomarkers - blood
C-reactive protein
C-Reactive Protein - analysis
C-Reactive Protein - metabolism
C-Reactive Protein - physiology
Comorbidity
Confounding Factors, Epidemiologic
Depression
Depression - metabolism
Depressive Disorder - metabolism
Female
Humans
Inflammation - blood
Inflammation - metabolism
Male
Meta-analysis
Reproducibility
Reproducibility of Results
Systematic review
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