Acquired disorders of phosphaturia: Beyond tumor-induced osteomalacia

Phosphate is an integral part of human cellular structure and function. Though most recognised disorders of phosphaturia are genetic in origin, phosphate loss due to acquired conditions is commonly encountered in clinical practice. Acquired hypophosphatemia is most commonly due to renal phosphate wa...

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Bibliographic Details
Published in:Baillière's best practice & research. Clinical endocrinology & metabolism 2024-03, Vol.38 (2), p.101839, Article 101839
Main Authors: Thakare, Sayali B., Jamale, Tukaram E., Memon, Saba S.
Format: Article
Language:English
Subjects:
Fanconi’s syndrome
NaPi transporters
phosphaturia
proximal renal tubular acidosis
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Summary:Phosphate is an integral part of human cellular structure and function. Though most recognised disorders of phosphaturia are genetic in origin, phosphate loss due to acquired conditions is commonly encountered in clinical practice. Acquired hypophosphatemia is most commonly due to renal phosphate wasting and can produce significant morbidity. It also heralds future kidney damage, and continued exposure can lead to progressive kidney injury and potentially renal failure. These conditions are a diverse group of disorders with common shared mechanisms causing loss of phosphate in the urine. Renal phosphate loss can occur as an isolated entity or as a part of generalised proximal tubular dysfunction, i.e., Fanconi's syndrome. An insight into the pathophysiological mechanisms of acquired phosphaturia can help clinicians monitor their patients better and avoid potential harms.
ISSN:1521-690X
1878-1594
DOI:10.1016/j.beem.2023.101839