Anticancer effects of vecuronium bromide and cisatracurium besylate on lung cancer cells (A549), in vitro

Neuromuscular blocking drugs are used in anesthesia and intensive care to provide skeletal muscle relaxation. However, literature has revealed that the effects of these drugs on cancer have not been widely studied. We tested the effects of two non-depolarising neuromuscular blocking drugs, vecuroniu...

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Bibliographic Details
Published in:Biomedicine & aging pathology 2014-10, Vol.4 (4), p.349-353
Main Authors: Yabasin, Iddrisu Baba, Ibrahim, Mohammed Mohammed, Adam, Abass, Wilfred, Sam-Awortwi, Ziem, Juventus Benogle, Gao, Peng, Kampo, Silvanus, Qingping, Wen
Format: Article
Language:English
Subjects:
A549 cells
Cisatracurium besylate
Cisplatin
Lung cancer
Vecuronium bromide
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Summary:Neuromuscular blocking drugs are used in anesthesia and intensive care to provide skeletal muscle relaxation. However, literature has revealed that the effects of these drugs on cancer have not been widely studied. We tested the effects of two non-depolarising neuromuscular blocking drugs, vecuronium bromide and cisatracurium besylate on lung cancer cells’ (A549) proliferation, migration and viability in the presence of a cytotoxic drug, cisplatin. We demonstrated in this study that both neuromuscular blocking agents inhibit lung cancer cells’ proliferation. In addition, the study revealed that vecuronium bromide and cisatracurium besylate was synergistic to cisplatin in reducing lung cancer cell proliferation. However, vecuronium inhibits lung cancer cells migration in vitro.
ISSN:2210-5220
2210-5220
DOI:10.1016/j.biomag.2014.07.004