Organic semiconducting polymer amphiphile for near-infrared-II light-triggered phototheranostics

Development of near-infrared-II (NIR-II) light responsive nano-agents with high photothermal stability, high photothermal conversion efficiency (PCE), and excellent biocompatibility for photoacoustic (PA) imaging-guided photothermal therapy (PTT) is of tremendous significance. In spite of the superi...

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Bibliographic Details
Published in:Biomaterials 2020-02, Vol.232, p.119684, Article 119684
Main Authors: Yin, Chao, Li, Xiaozhen, Wen, Guohua, Yang, Boguang, Zhang, Yachao, Chen, Xiaoyu, Zhao, Pengchao, Li, Shengliang, Li, Rui, Wang, Lidai, Lee, Chun-Sing, Bian, Liming
Format: Article
Language:English
Subjects:
Amphiphile
Animals
Infrared Rays
Mice
Nanoparticles
Photoacoustic imaging
Photoacoustic Techniques
Phototherapy
Photothermal therapy
Polymers
Second near-infrared window
Semiconducting polymer
Semiconductors
Theranostic Nanomedicine
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Summary:Development of near-infrared-II (NIR-II) light responsive nano-agents with high photothermal stability, high photothermal conversion efficiency (PCE), and excellent biocompatibility for photoacoustic (PA) imaging-guided photothermal therapy (PTT) is of tremendous significance. In spite of the superiority of organic semiconducting polymer nanoparticles (OSPNs) in PA imaging-guided PTT, the limited absorption in the first NIR (NIR-I) window and metastable nanostructure of OSPNs resulting from commonly used preparation methods based on nanoprecipitation or reprecipitation compromise their in vivo phototheranostic performance. Herein we design and synthesize a novel NIR-II absorbing organic semiconducting polymer amphiphile (OSPA) to enhance the structural stability of OSPNs. With prominent optical properties, low toxicity, and a suitable size, OSPA not only efficiently labels and kills cancer cells under NIR-II irradiation but also accumulates at the tumor of living mice upon intravenous injection, allowing efficient NIR-II light-triggered phototheranostics toward tumor. The developed OSPA has promising potential for fabricating multifunctional nanoplatforms to enable multimodal theranostics.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2019.119684