Association between the microbiota and women’s cancers – Cause or consequences?

Breast, ovarian and uterine cancers are the most common neoplasms among women. Several mechanisms may be involved in oncogenesis and these include environmental and genetic factors. Bacteria may affect the development of some cancers, with bacterial components, their products and metabolites interac...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2020-07, Vol.127, p.110203, Article 110203
Main Authors: Alizadehmohajer, Negin, Shojaeifar, Samaneh, Nedaeinia, Reza, Esparvarinha, Mojgan, Mohammadi, Forogh, Ferns, Gordon A., Ghayour-Mobarhan, Majid, Manian, Mostafa, Balouchi, Adele
Format: Article
Language:English
Subjects:
Bacterial microbiota
Breast Neoplasms - microbiology
Breast Neoplasms - virology
Carcinogenesis
DNA damage
Dysbiosis mechanisms
Female
Gastrointestinal Microbiome
Humans
Ovarian Neoplasms - microbiology
Ovarian Neoplasms - virology
Uterine Neoplasms - microbiology
Uterine Neoplasms - virology
Women’s cancers
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Summary:Breast, ovarian and uterine cancers are the most common neoplasms among women. Several mechanisms may be involved in oncogenesis and these include environmental and genetic factors. Bacteria may affect the development of some cancers, with bacterial components, their products and metabolites interacting with susceptible tissues. Commensalism and dysbiosis are important potential mechanisms involved in oncogenesis, and an effective strategy for diagnosis and treatment is required. The purpose of this review was to analyze the complex associations between these cancers in women, and the microbiota, specifically bacterial microbes. However, several cancers have an increased prevalence among individuals with HIV and HPV so the relationship between viral infections and malignancies in women is also referred to. We described how different phylum of bacteria, particularly in the gut, mammary tissue and vaginal microbiome may be involved in carcinogenesis; and we discuss the potential pathways involved: (I), that lead to cell proliferation, (II), immune system perturbation, (III), cell metabolic changes (e.g., hormonal factors), and (IV), DNA damage. Studies investigating the differences between the composition of the bacterial microbiota of healthy women compared to that present in various conditions, and the clinical trials are summarized for the few studies that have addressed the microbiota and related conditions, are also reviewed.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2020.110203