The Emerging Relationship Between Interstitial Fluid–Cerebrospinal Fluid Exchange, Amyloid-β, and Sleep

Amyloid-β (Aβ) plaques are a key histopathological hallmark of Alzheimer’s disease (AD), and soluble Aβ species are believed to play an important role in the clinical development of this disease. Emerging biomarker data demonstrate that Aβ plaque deposition begins decades before the onset of clinica...

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Bibliographic Details
Published in:Biological psychiatry (1969) 2018-02, Vol.83 (4), p.328-336
Main Authors: Boespflug, Erin L., Iliff, Jeffrey J.
Format: Article
Language:English
Subjects:
Alzheimer Disease - etiology
Alzheimer Disease - metabolism
Alzheimer's
Amyloid beta-Peptides - metabolism
Animals
Aquaporin-4
Astrocytes
Cerebrospinal fluid
Cerebrospinal Fluid - metabolism
CSF
Extracellular Fluid - metabolism
Glymphatic
Glymphatic System - metabolism
Humans
Interstitial fluid
Perivascular
Psychiatric/Mental Health
Sleep
Sleep Wake Disorders - metabolism
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