Ameroid rings for gradual chronic constriction of the sciatic nerve in rats: contribution of different nerves to neuropathic pain

Mononeuropathy was induced by placing an ameroid ring around the sciatic nerve and was compared with chronic constriction injury (CCI) of the sciatic nerve [Pain 33 (1988) 87] in rats. Mechanical allodynia was assessed and the role of sciatic and saphenous afferents (Aδ and C) in thermal hyperalgesi...

Full description

Saved in:
Bibliographic Details
Published in:Brain research bulletin 2004-08, Vol.64 (2), p.127-132
Main Authors: Tzabazis, A., Kim, P.H., Sweitzer, S.M., Yeomans, D.C.
Format: Article
Language:English
Subjects:
Ameroid ring
Analysis of Variance
Animals
Biocompatible Materials - adverse effects
Caseins
Constriction, Pathologic
Hydrogels - adverse effects
Hyperalgesia - physiopathology
Male
Mononeuropathies - complications
Neuralgia - etiology
Neuropathic
Pain
Pain Measurement
Physical Stimulation
Rat
Rats
Rats, Sprague-Dawley
Reaction Time
Reproducibility of Results
Saphenous
Sciatic
Sciatic Nerve - injuries
Sciatic Nerve - physiopathology
Skin - innervation
Skin - physiopathology
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mononeuropathy was induced by placing an ameroid ring around the sciatic nerve and was compared with chronic constriction injury (CCI) of the sciatic nerve [Pain 33 (1988) 87] in rats. Mechanical allodynia was assessed and the role of sciatic and saphenous afferents (Aδ and C) in thermal hyperalgesia investigated. A shorter duration of mechanical allodynia in ameroid rats as compared to CCI rats was observed. Thermal hyperalgesia was observed in the saphenous innervated skin of the hindpaw for Aδ and C nociceptors in ameroid and for Aδ nociceptors only in CCI rats, respectively. The sciatic innervated skin showed a thermal hypoalgesia with a fast onset for Aδ afferents and a slower onset for C afferents in CCI and ameroid rats. The duration of both thermal hypo- and hyperalgesia was longer in ameroid rats. We conclude that ameroid rings are a useful tool for the investigation of long-duration hyperalgesic effects of nerve injury, as the effects were more stable and seen for a longer time (>8 weeks) as compared to the CCI model. The uninjured saphenous afferents, in particular C fibers, mediate thermal hyperalgesia after chronic constriction of the sciatic nerve using an ameroid ring.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2004.05.006